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. 2021 Aug 16;22(4):737. doi: 10.3892/ol.2021.12998

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Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — STAT3 inhibitor HO-3867 reverses the positive effects of TAGLN2 overexpression on the migration, invasion and EMT of colorectal cancer cells. SW480 cell migration and invasion were measured by (A and B) wound healing and (C and D) Transwell assays, respectively (scale bar, 100 µm). (E) Expression of MMP2 and MMP9 was measured by western blotting. (F and G) Expression of proteins associated with EMT (N-cad, vimentin, ZEB2 and E-cad) was measured by reverse transcription-quantitative PCR and western blotting. *P<0.05, **P<0.01 and ***P<0.001. EMT, epithelial-mesenchymal transition; MMP, matrix metalloproteinase; TAGLN2, transgelin 2; OV, overexpressing plasmid; NC, negative control; STAT3, signal transducer and activator of transcription 3; N-cad, N-cadherin; E-cad, E-cadherin; ZEB2, zinc finger E-box binding homeobox 2.