Supplemental Figure 6.

NEUROG3 binding to the SOX4-CDKAL1 locus. Genome browser tracks showing NEUROG3, HA, and the CTRL CUT&RUN data at the SOX4-CDKAL1 locus. Coordinates are from hg19. The positions of NEUROG3 binding sites are highlighted in light blue (or in gray, when identified in a single dataset). Data of RNA-seq (EN_RNA), H3K27ac ChIP-seq (EN_K27AC), and the position of enhancers (EN Enhancers) from hESC-differentiated to endocrine progenitors were taken from Ref. [30] and http://meltonlab.rc.fas.harvard.edu/data/UCSC/SCbetaCellDiff_ATAC_H3K4me1_H3K27ac_WGBS_tracks.txt. Positions of hESC-derived multipotent progenitor cells (MPC) enhancers and cis-regulatory modules (CRM, defined as regions bound by at least two TF) are taken from Ref. [31]. Data from adult islets (Super-enhancers, Islet regulome, T2D/FG SNP and TAD-like regions) are taken from Ref. [32], isletregulome.org and http://epigenomegateway.wustl.edu/.