TABLE 1.

List of cargoes specific to eLBs and shared with the lysosomes.

Cargo	Function	Associated cellular process	References
Cargoes specific to eLBs
ATP-binding cassette sub-family A member 12 (ABCA12)	Lipid transporter	Formation of the skin barrier	Akiyama, 2011
Corneodesmosin (CDSN)	Adhesion glycoprotein of corneodesmosome	Formation of corneodesmosome	Jonca et al., 2002
Cathelicidin/LL-37	Antimicrobial peptide	Antimicrobial defense	Braff et al., 2005
β-defensin 2 (BD-2)	Antimicrobial peptide	Antimicrobial defense	Oren et al., 2003
Kallikrein-related peptidases (KLK): 5, 7, 14	Serine proteases	Desquamation	Borgono et al., 2007
Serine protease inhibitor Kazal-type 5 (SPINK5)	Serine protease inhibitor	Regulation of desquamation	Elias and Wakefield, 2014
Molecules associated with eLBs
Rab11A	Rab GTPase	eLB maturation or secretion?	Ishida-Yamamoto et al., 2007; Reynier et al., 2016
CLIP-170/restin	Peripherally associated to the limiting membrane	eLB biogenesis or secretion?	Raymond et al., 2008
Cargoes common to eLBs and lysosomes
Glucosylceramide Sphingomyelin Phospholipid Cholesterol	Lipid precursors	Formation of stratum corneum and maintenance of skin barrier	Reviewed in Elias et al. (2006); Feingold (2012)
β-glucocerebrosidase Sphingomyelinase Phospholipase A2 Steroid sulfatase	Lipid hydrolases	Formation of stratum corneum and maintenance of skin barrier	Reviewed in Elias et al. (2006); Feingold (2012)
Cathepsin D	Protease	Desquamation	Raymond et al., 2008
LAMP-1 LAMP-2 LIMP-2	Structural membrane proteins/receptor	eLB biogenesis?	Raymond et al., 2008
Rab7 Arl8b	GTPases peripherally associated to the limiting membrane	eLB biogenesis?	Raymond et al., 2008

“?” the cellular processes associated with these proteins require investigation.