Table 4.
μCT-Based Cortical Morphology at the Distal Femur and Femoral Diaphysis after Sham Surgery (T9 Laminectomy) or Severe Spinal Cord Injury (SCI) Alone or in Combination with Testosterone-Enanthate (SCI+TE) or TE Plus Finasteride (SCI+TE+FIN)
| SHAM (a) | SCI (b) | SCI+TE (c) | SCI+TE+FIN (d) | |
|---|---|---|---|---|
| Distal femur | ||||
| Tt.Ar, mm2 | 17.9 ± 0.53 | 17.0 ± 0.42 | 16.7 ± 0.35 | 17.6 ± 0.66 |
| Ct.Ar, mm2 | 7.36 ± 0.13b*,c*,d* | 6.30 ± 0.08a*,d | 5.95 ± 0.10a* | 5.90 ± 0.18a*,b |
| Ma.Ar, mm2 | 10.6 ± 0.46 | 10.7 ± 0.41 | 10.9 ± 0.31 | 11.7 ± 0.74 |
| Ct.Ar/Tt.Ar, % | 0.41 ± 0.01b*,c*,d* | 0.37 ± 0.01a*,d | 0.36 ± 0.01a* | 0.33 ± 0.02a*,b |
| Ct.Th, mm | 0.433 ± 0.010d | 0.404 ± 0.007 | 0.416 ± 0.013 | 0.396 ± 0.014a |
| TMD, g/mm2 | 1.215 ± 0.006c | 1.209 ± 0.004c* | 1.236 ± 0.006a,b* | 1.223 ± 0.007 |
| Femoral diaphysis | ||||
| Tt.Ar, mm2 | 12.4 ± 0.37 | 11.8 ± 0.20 | 11.9 ± 0.27 | 12.1 ± 0.47 |
| Ct.Ar, mm2 | 7.86 ± 0.17b*,d* | 7.28 ± 0.13a* | 7.46 ± 0.08 | 7.28 ± 0.15a* |
| Ma.Ar, mm2 | 4.53 ± 0.14 | 4.52 ± 0.11 | 4.54 ± 0.20 | 4.79 ± 0.37 |
| Ct.Ar/Tt.Ar, % | 0.64 ± 0.01 | 0.62 ± 0.01 | 0.62 ± 0.01 | 0.61 ± 0.02 |
| Ct.Th, mm | 0.726 ± 0.011d* | 0.693 ± 0.010 | 0.689 ± 0.006 | 0.678 ± 0.017a* |
| TMD, g/mm2 | 1.341 ± 0.005 | 1.342 ± 0.005 | 1.340 ± 0.005 | 1.331 ± 0.006 |
Values are means ± standard error; n = 9–12/group.
Letters a–d indicate differences from respectively labeled groups at p < 0.05 or *p < 0.01 (a = vs. SHAM, b = vs. SCI, c = vs. SCI+TE, and d = vs. SCI+TE+FIN).
μCT, microcomputed tomography; Tt.Ar, total area inside the periosteal envelope; Ct.Ar, cortical bone area; Ma.Ar, medullary area; Ct.Ar/Tt.Ar, cortical area fraction; Ct.Th, cortical thickness; TMD, tissue mineral density.