TABLE 3.
Mean life span of strains overexpressing Cu/ZnSOD
| Genotype | Life span (mean ± SEM) (days) of:
|
% Change (HP − Co)/Coa | P (HP versus Co) | |
|---|---|---|---|---|
| Co | HP | |||
| Expt 1 | ||||
| FLP1;SOD3A1(D) | 54.75 ± 0.60 | 60.53 ± 0.46 | +10.55* | <0.0001 |
| FLP1;SOD3B2(D) | 59.45 ± 0.88 | 57.38 ± 0.87 | −3.48 | 0.095 |
| FLP1;SOD2B2(D) | 48.97 ± 1.02 | 44.24 ± 0.80 | −9.66* | <0.0001 |
| FLP1;SOD2A(D) | 55.34 ± 1.25 | 45.91 ± 0.85 | −17.04* | <0.0001 |
| FLP1;SOD2A;SOD3A1(D) | 64.55 ± 0.76 | 65.55 ± 0.81 | +1.54 | 0.3734 |
| FLP1;SOD3A1(T) | 35.97 ± 1.00 | 39.71 ± 1.06 | +10.39* | 0.0102 |
| FLP1;SOD3B2(T) | 29.88 ± 0.96 | 34.54 ± 1.09 | +15.58* | 0.0020 |
| FLP1;SOD2B2(T) | 30.10 ± 0.73 | 31.29 ± 0.60 | +3.94 | 0.2076 |
| FLP1;SOD2A(T) | 31.68 ± 0.81 | 31.96 ± 0.68 | +0.90 | 0.7872 |
| FLP1;SOD2A;SOD3A1(T) | 39.88 ± 0.99 | 42.62 ± 1.11 | +6.87 | 0.0802 |
| Expt 2 | ||||
| FLP1;SOD3A1(D) | 55.22 ± 0.68 | 62.56 ± 0.60 | +13.28* | <0.0001 |
| FLP1;SOD3B2(D) | 53.87 ± 0.85 | 53.09 ± 0.84 | −1.46 | 0.5092 |
| FLP1;SOD2B2(D) | 49.16 ± 0.94 | 39.72 ± 0.80 | −19.22* | <0.0001 |
| FLP1;SOD2A(D) | 55.76 ± 1.25 | 46.90 ± 0.92 | −15.87* | <0.0001 |
| FLP1;SOD2A;SOD3A1(D) | 58.46 ± 0.72 | 61.74 ± 0.90 | +5.61* | 0.0046 |
| FLP1;SOD3A1(T) | 34.59 ± 1.21 | 39.50 ± 1.14 | +14.20* | 0.0028 |
| FLP1;SOD3B2(T) | 32.41 ± 0.92 | 38.93 ± 1.19 | +20.11* | <0.0001 |
| FLP1;SOD2B2(T) | 31.16 ± 0.64 | 30.71 ± 0.56 | −1.44 | 0.5962 |
| FLP1;SOD2A(T) | 31.21 ± 0.68 | 31.38 ± 0.68 | +0.54 | 0.8650 |
| FLP1;SOD2A;SOD3A1(T) | 35.89 ± 1.11 | 39.75 ± 1.33 | +10.77* | 0.0258 |
a
∗, statistically significant change.