Table A.

Target Doses of Guideline-Directed Medical Therapies

ACE Inhibitors	Target Dose	Total Daily Target Dose	50% of Total Daily Target Dose
Captopril	50 mg, three times daily	150 mg	75 mg
Enalapril	10 mg, twice daily	20 mg	10 mg
Lisinopril	20 mg, once daily	20 mg	10 mg
Ramipril	10 mg, once daily	10 mg	5 mg
Perindopril	8 mg, once daily	8 mg	4 mg
Trandolapril	4 mg, once daily	4 mg	2 mg
Benazepril	40 mg, once daily	40 mg	20 mg
Fosinopril	40 mg, once daily	40 mg	20 mg
Quinapril	20 mg, twice daily	40 mg	20 mg
ARB
Candesartan	32 mg, once daily	32 mg	16 mg
Losartan	100 mg, once daily*	100 mg	50 mg
Valsartan	160 mg, twice daily	320 mg	160 mg
Irbesartan	300 mg, once daily	300 mg	150 mg
Telmisartan	80 mg, once daily	80 mg	40 mg
Olmesartan	40 mg, once daily	40 mg	20 mg
Azilsartan	80 mg, once daily	80 mg	40 mg
ARNI
Sacubitril/valsartan	97/103 mg, twice daily	194/206 mg	98/102 mg†
Evidence-Based Beta-Blockers
Bisoprolol	10 mg, once daily	10 mg	5 mg
Carvedilol	25 mg, twice daily	50 mg	25 mg
Carvedilol extended release	80 mg, once daily	80 mg	40 mg
Metoprolol succinate sustained release	200 mg, once daily	200 mg	100 mg

Sources for target doses include: 2013 ACCF/AHA heart failure clinical practice guideline,⁷ 2017 ACC/AHA/HFSA heart failure guideline update,⁴ 2017 ACC expert consensus decision pathway for optimization of heart failure treatment,¹⁰ and FDA-approved labels.⁶⁸

^*ACC/AHA Guidelines recommend losartan 150 mg as target dose. However, because current FDA-approved labeling has 100 mg as the maximal dose, the 100-mg dose is used in the performance measure.

^†The sacubitril 98 mg and valsartan 102 mg total daily dosing (49/51 mg twice daily) is considered fulfilling the 50% of target dosing criteria. ACE indicates angiotensin–converting enzyme; ARB, angiotensin II receptor blocker; and ARNI, angiotensin receptor–neprilysin inhibitor.