Fig. 4.

Publications relating to the third generation blood transcriptome fingerprinting framework. The present work is part of a series of articles that include bioinformatic resources (in orange) and use cases (in blue). In addition to the R package that has been developed and is presented here, another resource paper describes the construction and functional characterization of the third repertoire of our blood transcriptional modules ([1]: Transcriptional Fingerprinting Framework = TFF). Use cases for this framework include the design of targeted transcript panels and assays(Transcriptional Fingerprinting Assays = TFA). One such assay was developed as a generic immune monitoring platform [4], while a second was custom designed to monitor immune responses to SARS-CoV-2 infection [3]. Another use case employed the Gen3 TFF and R package to perform a meta-analysis of six independent datasets profiling the abundance of blood transcripts in patients with an RSV infection [5]. Finally work that was published recently outlined another use case in which the same resources were used to pinpoint discrete inflammation signatures associated with inflammation in patients with psoriasis [6]