Table 2.

Number of unique significant (Bonferroni corrected) associations for 5 neuropsychiatric disorders across different gene-based methods

	E-MAGMA	MAGMA	S-PrediXcan	FUSION	SMR
ADHD	5	17	7	10	–
AUT	1	5	2	4	–
BIP	32	47	20	31	0
DEP	119	190	89	45	7
SCZ	254	460	210	236	37

Note: Association statistics using SMR for ADHD and AUT could not be calculated because publicly available summary statistics for these disorders do not include SNP minor allele frequency. Supplementary Table S6 shows the number of associations for each method after restricting to genes with genetically regulated levels of gene expression, as defined by S-PrediXcan and TWAS FUSION.