Table 2.
B shape = Flat |
B shape = I |
B shape = T |
B shape = Random |
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---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
TR. | TR. | TR. | LM | LASSO | TR. | TR. | TR. | LM | LASSO | TR. | TR. | TR. | LM | LASSO | TR. | TR. | TR. | LM | LASSO | |
true | AIC | BIC | true | AIC | BIC | true | AIC | BIC | true | AIC | BIC | |||||||||
0.125 | ||||||||||||||||||||
TPR | 0.371 | 0.370 | 0.371 | 0.274 | 0.683 | 0.695 | 0.698 | 0.695 | 0.214 | 0.664 | 0.736 | 0.744 | 0.981 | 0.669 | 0.832 | 0.626 | 0.849 | 0.892 | 0.396 | 0.796 |
FDR | 0.044 | 0.047 | 0.044 | 0.257 | 0.275 | 0.222 | 0.146 | 0.222 | 0.331 | 0.429 | 0.127 | 0.094 | 0.442 | 0.076 | 0.317 | 0.043 | 0.032 | 0.027 | 0.053 | 0.184 |
F-measure | 0.530 | 0.529 | 0.530 | 0.398 | 0.702 | 0.731 | 0.756 | 0.731 | 0.321 | 0.613 | 0.797 | 0.813 | 0.711 | 0.776 | 0.750 | 0.756 | 0.899 | 0.929 | 0.557 | 0.806 |
0.25 | ||||||||||||||||||||
TPR | 0.649 | 0.649 | 0.649 | 0.564 | 0.753 | 0.795 | 0.870 | 0.873 | 0.554 | 0.855 | 0.868 | 0.899 | 0.973 | 0.809 | 0.939 | 0.860 | 0.872 | 0.969 | 0.709 | 0.914 |
FDR | 0.033 | 0.033 | 0.033 | 0.141 | 0.320 | 0.235 | 0.118 | 0.116 | 0.158 | 0.423 | 0.141 | 0.057 | 0.288 | 0.061 | 0.332 | 0.032 | 0.034 | 0.044 | 0.030 | 0.189 |
F-measure | 0.773 | 0.773 | 0.773 | 0.679 | 0.714 | 0.779 | 0.875 | 0.877 | 0.666 | 0.688 | 0.863 | 0.919 | 0.807 | 0.869 | 0.780 | 0.911 | 0.915 | 0.962 | 0.819 | 0.860 |
1 | ||||||||||||||||||||
TPR | 0.954 | 0.954 | 0.954 | 0.932 | 0.965 | 0.815 | 0.914 | 0.914 | 0.895 | 0.957 | 0.967 | 0.979 | 0.980 | 0.971 | 0.990 | 0.961 | 0.960 | 0.961 | 0.936 | 0.967 |
FDR | 0.036 | 0.037 | 0.036 | 0.093 | 0.412 | 0.238 | 0.107 | 0.106 | 0.103 | 0.475 | 0.081 | 0.055 | 0.053 | 0.055 | 0.350 | 0.025 | 0.026 | 0.025 | 0.025 | 0.231 |
F-measure | 0.954 | 0.954 | 0.954 | 0.919 | 0.730 | 0.785 | 0.902 | 0.903 | 0.895 | 0.677 | 0.942 | 0.962 | 0.963 | 0.957 | 0.784 | 0.968 | 0.967 | 0.968 | 0.955 | 0.856 |
Note: TPR = true positive rate; FDR = false discovery rate; d indicates the effect strength of causal omics variables. For TR and LM, a variable is selected as important if P-value < 0.05. The best performed methods among TR.AIC, LM and LASSO, judged by F-measures, are shown in shaded cells.