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. Author manuscript; available in PMC: 2021 Aug 26.
Published in final edited form as: Environ Res. 2021 Mar 27;197:111084. doi: 10.1016/j.envres.2021.111084

Table 3.

Pairwise comparisons of saliva and fecal microbial community beta diversities (Bray-Curtis, unweighted Unifrac, weighted Unifrac and Jaccard distances)2 (N=63)

Saliva microbiome Fecal microbiome
Pairwise Comparisons1 Bray-Curtis Unweighted UniFrac Weighted Unifrac Jaccard distances Omnibus test Bray-Curtis Unweighted UniFrac Weighted Unifrac Jaccard distances Omnibus test
T2 vs. T1 0.005 0.734 0.115 0.135 0.017 0.588 0.264 0.574 0.142 0.347
T3 vs. T1 0.016 0.286 0.014 0.002 0.007 0.411 0.661 0.513 0.501 0.777
T3 vs. T2 0.806 0.935 0.594 0.702 0.927 0.164 0.044 0.230 0.039 0.119
T4 vs. T1 0.123 0.990 0.271 0.076 0.227 0.831 0.826 0.704 0.308 0.665
T4 vs. T2 0.801 0.748 0.896 0.190 0.477 0.863 0.154 0.806 0.522 0.377
T4 vs. T3 0.557 0.586 0.656 0.930 0.910 0.843 0.731 0.344 0.848 0.700
T5 vs. T1 <0.001 0.008 <0.001 <0.001 <0.001 0.508 0.491 0.285 0.048 0.136
T5 vs. T2 0.002 0.225 0.008 0.228 0.006 0.099 0.240 0.057 0.105 0.180
T5 vs. T3 0.005 0.084 0.033 0.121 0.018 0.693 0.902 0.453 0.263 0.586
T5 vs. T4 0.001 0.042 0.022 0.016 0.002 0.180 0.580 0.045 0.098 0.145
1

Pairwise comparisons of interventions (T1=baseline; T2=end of Diet A phase, conventional processed meat for Groups 1 and 2; T3=end of Diet B phase, poultry wash out for Groups 1 and 2; T4=end of Diets C or D phase, conventional processed meats with phytochemicals or low nitrite processed meat with phytochemicals, respectively; T5=end of high nitrate-enriched water + either Diet A, B, C, or D phase

2

P-values of pairwise comparisons estimated using a Generalized Linear Mixed Model - Microbiome Regression-based Kernel Association Test (GLMM-MiRKAT) adjusted for age (years, continuous), sex, and body mass index (kg/m2, continuous). All statistical tests were two-sided.