Figure 2 -. Global distribution of HLA alleles that are either strong or weak binders of SARS-CoV-2 epitopes. Upper left panel: The frequency of the predicted SARS-CoV-2 strong binder HLA-B*15:03 is high in African populations (usually > 8%) and rare among Europeans, Asians, and Americans. Lower left panel: The frequency of the predicted SARS-CoV-2 weak binder HLA-B*14:02 is high in American populations, particularly Brazil, and also among European and Africans. Upper right panel: The frequency of the cosmopolitan allele A*24:02. Lower right panel: The frequency of the Asian-restricted B*46:01 allele. Frequency data were obtained from the Brazilian and 1000 Genomes high-coverage sequencing data processed with specific HLA bioinformatics workflow (Naslavsky et al., 2020), and from the allelefrequencies.net website (Gonzalez-Galarza et al., 2020).