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. Author manuscript; available in PMC: 2021 Aug 26.
Published in final edited form as: Curr Opin Genet Dev. 2021 Jan 7;66:63–69. doi: 10.1016/j.gde.2020.12.004

Figure 1. Aging increases risk for clonal hematopoiesis and hematological malignancies.

Figure 1

A) Representation of CH driver mutations as a function of aging. After clonal expansion, CH clones may acquire additional secondary mutations that induce malignant transformation. B) Prevalence of CHIP and AML as a function of age. Data for the prevalence of CHIP were adopted from studies found in Jaiswal et al. 2014 [9]. Prevalence of AML among patients in the US were reported using Surveillance Research Program, National Cancer Institute SEER*Explorer (seer.cancer.gov/explorer) for AML patients diagnosed between 2013–2017 [57].