Figure 1.

(A) Schematic view of one ASIC subunit: Each subunit has two hydrophobic transmembrane domains, a large cysteine-rich extracellular loop, and short intracellular N- and C- termini; (B) phylogenetic tree illustrating the relationship of zASICs and other ASICs from human (h) and rat (r) (Paukert et al., 2004 modified).