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Synthesis of N-aryltriazole monocationic peptidomimetics 10–16. i. HOBt (1.1 eq), EDCI.HCl (1.1 eq), Et3N (1.0 eq), CH2Cl2, rt, 16 h. ii. R3C≡CH, CuSO4.5H2O (0.2 eq), Na.ascorbate (0.4 eq), t-BuOH:H2O (4:1), rt, 16 h. iii. TFA/H2O/DCM, rt, 16 h; then HCl in Et2O.
