Table 1.
Effect of mild and severe chronic intermittent hypoxia (CIH) exposure on weight, fasting glycemia, fasting insulinemia, and insulin resistance calculated by the homeostatic model assessment (HOMA-IR) method in control and high-fat (HF) animals.
| Mild | Severe | |||||
|---|---|---|---|---|---|---|
| Control | CIH | Control | CIH | HF | HFIH | |
| Weight (g) | 382 ± 28 | 355 ± 8 | 492 ± 9 | 457 ± 10 * | 696 ± 7 | 609 ± 38 * |
| Glycemia (mmol/L) | 5.12 ± 0.20 | 4.78 ± 0.26 | 4.84 ± 0.13 | 4.63 ± 0.14 | 4.99 ± 0.13 | 4.76 ± 0.10 |
| Insulin (pmol/L) | 231.40 ± 31.23 | 529.70 ± 9.65 **** | 300.70 ± 61.53 | 570.10 ± 61.53 * | 657.50 ± 104.70 * | 631.90 ± 96.89 |
| HOMA-IR | 5.22 ± 0.65 | 12.00 ± 0.84 **** | 6.18 ± 0.91 | 12.02 ± 1.64 ** | 15.28 ± 1.45 ** | 14.22 ± 2.37 |
Data are means ± SEM of six to eight rats. Two-way ANOVA with Bonferroni multiple comparison test: * p < 0.05, ** p < 0.01, and **** p < 0.0001 compared with control animals of the respective groups.