Table 4.

Molecules targeted by sirt6 and sirt7 for regulation of the oxidative stress and the activator of sirt6 and sirt7.

	Target Molecules	Kidney Model	Activator
Sirt6	NF-ĸB PGC-1α p53 FoxO1 FoxO3a AMPK eNOS Nrf2	LPS nephropathy Cisplatin-induced Acute kidney injury	CR
Sirt7	GABPb1 NF-ĸB HIF-1α	Cisplatin-induced Acute kidney injury	CR Resveratrol

Abbreviations: Nuclear factor kappa β: NF-ĸB, Peroxisome proliferator-activated receptor-γ coactivator-1α: PGC-1α, Forkhead Box O: FoxO, AMP-activated protein kinase: AMPK, Endothelial nitric oxide synthase: eNOS, Nuclear factor erythroid 2-related factor 2: Nrf2, GA-binding protein subunit beta1: GABPb1, Hypoxia-inducible factor: HIF.