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. 2021 Jul 29;10(8):1224. doi: 10.3390/antiox10081224

Figure 1.

Figure 1

(A) Toxic profile of human erythrocytes incubated with increasing nitrone concentrations for 12 h a 37 °C. Results are expressed as percentage of hemolysis; (B) inhibition of hemolysis (%) after treatment with nitrones for 1 h at 37 °C followed by addition of PBS with or without AAPH (final concentration AAPH, 50 mM) and incubation for 12 h at 37 °C in a gently shaking incubator. * p < 0.05 and ** p < 0.001 are related to untreated RBCs; (C) cytotoxicity of nitrones in ARPE19: cells are treated with increasing concentrations of nitrones for 48 h in complete culture medium; (D) effect of nitrones on ARPE19 cells after AAPH exposure: cells are treated with selected concentrations of nitrones for 24 h followed by treatment with 15 mM AAPH for 6 h. Cell viability is measured by MTT assay. * p < 0.05 is related to AAPH-treated cells.