Table 1.
Changes in overall and intensive care unit (ICU) consumption of anti-infectives for systemic use, 2019–2020.
| DDD/100 Bed-Days | DDD/100 Discharges | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Service | ATC Classification | 2019 | 2020 | Variation (%) | p | 2019 | 2020 | Variation (%) | p | |
| Overall | J01 Antibacterials for systemic use | 69.38 | 70.99 | 2.31 | <0.001 | 407.41 | 424.30 | 4.15 | <0.001 | |
| J01C Penicillins | 23.63 | 21.70 | −8.18 | <0.001 | 138.76 | 129.69 | −6.53 | <0.001 | ||
| J01CR Combinations of penicillins. incl. beta-lactamase inhibitors | 18.26 | 16.80 | −7.98 | <0.001 | 107.23 | 100.44 | −6.33 | <0.001 | ||
| J01DBCDE Cephalosporins | 14.10 | 15.19 | 7.78 | <0.001 | 82.78 | 90.82 | 9.71 | <0.001 | ||
| J01DD Third-generation cephalosporins | 7.56 | 9.51 | 25.72 | <0.001 | 44.40 | 56.82 | 27.97 | <0.001 | ||
| J01DE Fourth-generation cephalosporins | 0.64 | 0.65 | 2.05 | 0.03 | 3.75 | 3.89 | 3.87 | <0.001 | ||
| J01DH Carbapenems | 5.01 | 5.16 | 2.93 | <0.001 | 29.41 | 30.82 | 4.77 | <0.001 | ||
| J01DI Other cephalosporins and penems | 0.29 | 0.37 | 29.00 | <0.001 | 1.68 | 2.20 | 31.32 | <0.001 | ||
| J01FA Macrolides | 3.26 | 6.69 | 105.40 | <0.001 | 19.13 | 40.00 | 109.08 | <0.001 | ||
| J01G Aminoglycoside antibacterials | 1.82 | 1.63 | −10.72 | <0.001 | 10.69 | 9.71 | −9.12 | <0.001 | ||
| J01M Quinolone antibacterials | 8.48 | 7.20 | −15.01 | <0.001 | 49.77 | 43.06 | −13.49 | <0.001 | ||
| J01X Other antibacterials | 8.89 | 9.39 | 5.72 | <0.001 | 52.18 | 56.15 | 7.61 | <0.001 | ||
| J01XA Glycopeptide antibacterials | 2.56 | 2.75 | 7.43 | <0.001 | 15.01 | 16.42 | 9.36 | <0.001 | ||
| J01XB Polymyxins | 0.39 | 0.34 | −12.96 | <0.001 | 2.28 | 2.02 | −11.40 | <0.001 | ||
| J01XX Other antibacterials | 3.70 | 4.01 | 8.45 | <0.001 | 21.72 | 23.98 | 10.39 | <0.001 | ||
| J02A Antimycotics for systemic use | 3.11 | 3.43 | 10.25 | <0.001 | 18.24 | 20.47 | 12.22 | <0.001 | ||
| J02AB Imidazole derivatives | 0.00 | 0.00 | −81.25 | <0.001 | 0.03 | 0.01 | −80.99 | <0.001 | ||
| J02AC Triazole derivatives | 2.61 | 2.81 | 7.85 | <0.001 | 15.31 | 16.81 | 9.78 | <0.001 | ||
| J02AX Other antimycotics for systemic use | 0.39 | 0.44 | 14.62 | <0.001 | 2.27 | 2.64 | 16.67 | <0.001 | ||
| ICU | J01 Antibacterials for systemic use | 114.23 | 112.77 | −1.28 | <0.001 | 508.18 | 627.21 | 23.42 | <0.001 | |
| J01C Penicillins | 32.92 | 27.40 | −16.78 | <0.001 | 146.46 | 152.38 | 4.04 | <0.001 | ||
| J01CR Combinations of penicillins. incl. beta-lactamase inhibitors | 23.24 | 18.74 | −19.35 | <0.001 | 103.37 | 104.23 | 0.84 | 0.21 | ||
| J01DBCDE Cephalosporins | 17.26 | 18.20 | 5.46 | <0.001 | 76.80 | 101.26 | 31.84 | <0.001 | ||
| J01DD Third-generation cephalosporins | 12.11 | 13.78 | 13.82 | <0.001 | 53.87 | 76.66 | 42.30 | <0.001 | ||
| J01DE Fourth-generation cephalosporins | 1.20 | 1.98 | 65.04 | <0.001 | 5.35 | 11.03 | 106.35 | <0.001 | ||
| J01DH Carbapenems | 14.66 | 14.02 | −4.32 | <0.001 | 65.20 | 77.99 | 19.62 | <0.001 | ||
| J01DI Other cephalosporins and penems | 0.87 | 1.19 | 36.09 | <0.001 | 3.88 | 6.60 | 70.13 | <0.001 | ||
| J01FA Macrolides | 7.62 | 13.60 | 78.44 | <0.001 | 33.90 | 75.62 | 123.09 | <0.001 | ||
| J01G Aminoglycoside antibacterials | 4.11 | 3.88 | −5.64 | <0.001 | 18.30 | 21.58 | 17.97 | <0.001 | ||
| J01M Quinolone antibacterials | 9.33 | 8.18 | −12.39 | <0.001 | 41.52 | 45.48 | 9.54 | <0.001 | ||
| J01X Other antibacterials | 19.34 | 19.67 | 1.69 | 0.01 | 86.04 | 109.38 | 27.13 | <0.001 | ||
| J01XA Glycopeptide antibacterials | 5.41 | 5.65 | 4.49 | <0.001 | 24.07 | 31.45 | 30.64 | <0.001 | ||
| J01XB Polymyxins | 1.17 | 1.64 | 40.27 | <0.001 | 5.20 | 9.11 | 75.36 | <0.001 | ||
| J01XX Other antibacterials | 10.46 | 10.82 | 3.40 | <0.001 | 46.55 | 60.18 | 29.28 | <0.001 | ||
| J02A Antimycotics for systemic use | 12.35 | 11.81 | −4.35 | <0.001 | 54.93 | 65.68 | 19.58 | <0.001 | ||
| J02AB Imidazole derivatives | 0.00 | 0.00 | - | - | 0.00 | 0.00 | - | - | ||
| J02AC Triazole derivatives | 8.91 | 8.36 | −6.17 | <0.001 | 39.62 | 46.48 | 17.31 | <0.001 | ||
| J02AX Other antimycotics for systemic use | 3.00 | 2.79 | −6.96 | <0.001 | 13.36 | 15.54 | 16.33 | <0.001 | ||
ICU: Intensive care unit; DDD: Defined daily doses; ATC: Anatomical therapeutic chemical.