Table 1.
Baseline characteristics of adenoma case patients as well as age and sex frequency-matched control participants.
| Characteristics | Controls | Overall CRA Cases | Advanced CRA Cases | ||||||
|---|---|---|---|---|---|---|---|---|---|
| n | Median (IQR) | % | n | Median (IQR) | % | n | Median (IQR) | % | |
| Age (years) | 100 | 60 (57–67) | - | 100 | 60 (57–67) | - | 71 | 60 (56–67) | - |
| Sex | |||||||||
| Female | 55 | - | 55.0 | 55 | - | 55.0 | 43 | - | 60.6 |
| Male | 45 | - | 45.0 | 45 | - | 45.0 | 28 | - | 39.4 |
| BMI (kg/m2) | |||||||||
| <25 | 34 | - | 34.7 | 31 | - | 32.3 | 26 | - | 38.8 |
| 25–< 30 | 46 | - | 46.9 | 48 | - | 50.0 | 30 | - | 44.8 |
| ≥30 | 18 | - | 18.4 | 17 | - | 17.7 | 11 | - | 16.4 |
| Smoking status | |||||||||
| Never smoker | 58 | - | 58.6 | 42 | - | 42.4 | 30 | - | 42.3 |
| Former smoker | 33 | - | 33.3 | 45 | - | 45.5 | 31 | - | 43.7 |
| Current smoker | 8 | - | 8.1 | 12 | - | 12.1 | 10 | - | 14.1 |
| Physical activity | |||||||||
| Inactive | 44 | - | 47.3 | 42 | - | 45.7 | 31 | - | 47.7 |
| Sedentary | 33 | - | 35.5 | 28 | - | 30.4 | 23 | - | 35.4 |
| Vigorously | 16 | - | 17.2 | 22 | - | 23.9 | 11 | - | 16.9 |
|
Red and processed
meat consumption a |
|||||||||
| Low | 12 | - | 12.2 | 14 | - | 14.0 | 12 | - | 16.9 |
| Intermediate | 70 | - | 71.4 | 80 | - | 80.0 | 54 | - | 76.1 |
| High | 16 | - | 16.3 | 6 | - | 6.0 | 5 | - | 7.0 |
| SHP (μmol/L) | 100 | 258 (205–290) | - | 100 | 228 (200–275) | - | 71 | 218 (188–265) | - |
| hs-CRP (mg/L) | 91 | 1.44 (0.59–3.26) | - | 97 | 1.21 (0.64–1.99) | - | 70 | 1.16 (0.54–1.96) | - |
| Ferritin (ng/mL) | 68 | 86.2 (45.6–190.4) | - | 70 | 78.7 (52.4–140.9) | - | 51 | 73.4 (52.4–133.9) | - |
| Transferrin (mg/dL) | 97 | 224 (207–251) | - | 96 | 229 (205–262) | - | 67 | 221 (203–253) | - |
| Total serum iron (μmol/L) | 99 | 13.9 (11.0–18.1) | - | 100 | 15.2 (11.3–19.7) | - | 71 | 15.2 (11.0–19.5) | - |
| Transferrin saturation (%) | 97 | 23.9 (18.8–30.1) | - | 96 | 26.7 (21.6–34.7) | - | 67 | 27.2 (21.6–35.2) | - |
Abbreviations: BMI, body mass index; hs-CRP, high-sensitive C-reactive protein; IQR, interquartile range; SHP, total thiol levels. Note: Numbers printed in bold: Statistically significant difference of controls with overall CRA cases and advanced CRA cases (p < 0.05; chi-squared test for categorical variables and Wilcoxon rank-sum test for continuous variables). a Low red and processed meat consumption was defined as both red and processed meat consumption no more than once per week. High red and processed meat consumption was defined as both daily red and processed meat consumption or either red or processed meat consumption several times per day. All others were grouped in the intermediate consumption category.