Table 5.
Odds ratios and 95% confidence intervals for the associations of biomarkers of oxidative stress, inflammation and body-iron stores concentration tertiles with overall as well as advanced colorectal adenoma.
| Biomarker | Categories | Concentrations | n control | Overall Colorectal Adenoma | Advanced Colorectal Adenoma | ||||
|---|---|---|---|---|---|---|---|---|---|
| n case | Model 1 OR (95%CI) a |
Model 2 OR (95%CI) b |
n case | Model 1 OR (95%CI) a |
Model 2 OR (95%CI) b |
||||
| SHP (μmol/L) | Tertile 1 | ≤216 | 34 | 40 | Ref. | Ref. | 33 | Ref. | Ref. |
| Tertile 2 | >216–≤280 | 33 | 37 | 1.07 (0.52–2.22) | 0.86 (0.40–1.87) | 25 | 0.76 (0.34–1.68) | 0.58 (0.25–1.40) | |
| Tertile 3 | >280 | 33 | 23 | 0.73 (0.32–1.69) | 0.65 (0.27–1.56) | 13 | 0.32 (0.12–0.89) | 0.29 (0.10–0.84) | |
| hs-CRP (mg/L) | Tertile 1 | ≤0.83 | 30 | 33 | Ref. | Ref. | 26 | Ref. | Ref. |
| Tertile 2 | >0.83–≤2.02 | 30 | 41 | 1.22 (0.58–2.54) | 1.37 (0.65–2.92) | 29 | 1.12 (0.50–2.52) | 1.50 (0.63–3.56) | |
| Tertile 3 | >2.02 | 31 | 23 | 0.65 (0.28–1.51) | 0.77 (0.32–1.91) | 15 | 0.46 (0.17–1.24) | 0.64 (0.22–1.87) | |
| Ferritin (ng/mL) | Tertile 1 | ≤56.2 | 23 | 21 | Ref. | Ref. | 15 | Ref. | Ref. |
| Tertile 2 | >56.2–≤138.6 | 23 | 31 | 1.36 (0.55–3.31) | 1.81 (0.74–4.39) | 25 | 1.86 (0.67–5.13) | 1.87 (0.67–5.25) | |
| Tertile 3 | >138.6 | 22 | 18 | 0.88 (0.32–2.41) | 0.93 (0.32–2.74) | 11 | 0.77 (0.24–2.49) | 0.72 (0.21–2.51) | |
| Transferrin (mg/dL) | Tertile 1 | ≤212 | 33 | 29 | Ref. | Ref. | 22 | Ref. | Ref. |
| Tertile 2 | >212–≤241 | 33 | 27 | 1.26 (0.57–2.78) | 0.97 (0.44–2.16) | 20 | 1.07 (0.45–2.54) | 0.79 (0.32–1.96) | |
| Tertile 3 | >241 | 32 | 40 | 1.45 (0.68–3.10) | 1.14 (0.51–2.50) | 25 | 1.03 (0.44–2.42) | 0.84 (0.34–2.05) | |
|
Total serum iron
(μmol/L) |
Tertile 1 | ≤11.9 | 33 | 28 | Ref. | Ref. | 21 | Ref. | Ref. |
| Tertile 2 | >11.9–≤15.9 | 33 | 27 | 1.12 (0.50–2.49) | 1.07 (0.47–2.45) | 19 | 0.94 (0.38–2.28) | 0.99 (0.39–2.53) | |
| Tertile 3 | >15.9 | 33 | 45 | 2.04 (0.95–4.39) | 2.07 (0.91–4.70) | 31 | 1.63 (0.71–3.75) | 2.10 (0.82–5.40) | |
|
Transferrin
saturation (%) |
Tertile 1 | ≤20.7 | 33 | 19 | Ref. | Ref. | 15 | Ref. | Ref. |
| Tertile 2 | >20.7–≤27.4 | 32 | 31 | 2.24 (0.95–5.28) | 2.07 (0.86–5.01) | 19 | 1.56 (0.59–4.10) | 1.56 (0.54–4.48) | |
| Tertile 3 | >27.4 | 32 | 46 | 3.98 (1.70–9.32) | 3.05 (1.30–7.19) | 33 | 3.48 (1.38–8.75) | 2.71 (1.03–7.13) | |
Note: Numbers in bold reflect the statistically significant estimates compared to the reference (p < 0.05). Abbreviations: CRA, colorectal adenoma; Carr U, Caratelli units; hs-CRP, high sensitive C-reactive protein; SHP, total thiol levels. a The logistic regression model is adjusted for age, sex, BMI, physical activity, smoking status, red and processed meat consumption. b The logistic regression model is adjusted for variables of model 1, SHP, hs-CRP, ferritin and transferrin saturation (except for analyses with transferrin and total serum iron, which were not adjusted for transferrin saturation because they are being used to calculate transferrin saturation).