Table 3.
Minimum inhibitory concentration (μg mL−1) of the compounds 39a–39i.
| Compound | Antitubercular Activity |
Antibacterial Activity | Antifungal Activity |
|||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Gram-Positive Bacteria | Gram-Negative Bacteria |
|||||||||
| Mt | Sa | Se | Ml | Bc | Ec | Pa | Kp | An | Af | |
| 39a | 125.5 | 62.5 | 62.5 | 125 | 62.5 | 62.5 | 125 | 31.25 | 62.5 | 31.25 |
| 39b | 62.5 | 31.25 | 31.25 | 62.5 | 31.25 | 62.5 | 62.5 | 31.25 | 31.25 | 15.62 |
| 39c | 3.9 | 7.81 | 1.95 | 3.9 | 7.81 | 7.81 | 7.81 | 1.95 | 3.9 | 1.95 |
| 39d | 7.81 | 7.81 | 3.9 | 7.81 | 7.81 | 7.81 | 7.81 | 3.9 | 7.81 | 3.9 |
| 39e | 62.5 | 62.5 | 31.25 | 62.5 | 62.5 | 62.5 | 62.5 | 31.25 | 62.5 | 31.25 |
| 39f | 3.9 | 125 | 3.9 | 3.9 | 7.81 | 7.81 | 3.9 | 1.95 | 3.9 | 1.95 |
| 39g | 7.81 | 15.62 | 3.9 | 7.81 | 7.81 | 15.62 | 7.81 | 3.9 | 7.81 | 3.9 |
| 39h | >125 | 125 | 125 | >125 | >125 | 125 | >125 | 62.5 | 62.5 | 62.5 |
| 39i | 125 | 125 | 125 | >125 | 125 | 62.5 | 125 | 62.5 | 62.5 | 31.25 |
| Standard | 0.97 | 125 | 1.95 | 3.9 | 7.81 | 7.81 | 3.9 | 1.95 | 7.81 | 3.9 |
Mb: Mycobacterium tuberculosis, Sa: Staphylococcus aureus ATCC 9144, Se: Staphylococcus epidermidis ATCC 155, Ml: Micrococcus luteus ATCC 4698, Bacillus cereus ATCC 11778, Ec: Escherichia coli ATCC 25922, Pa: Pseudomonas aeruginosa ATCC 2853, Kp: Klebsiella pneumoniae ATCC 11298, An: Aspergillus niger ATCC 9029, Af: Aspergillus fumigatus ATCC 46645. Standard: Isoniazid: reference standard against M. tuberculosis, Ciprofloxacin: standard for other bacteria, Ketoconazol: reference standard for fungi.