Table 12.

Gyrase and Topoisomerase IV Inhibition and antibacterial activities of the compounds.

Compound	Enzyme Inhibiton Data Ki (μM)			Minimum Inhibitory Concentration (μg/mL)
	S. aureus gyrase	E. coli gyrase	E. coli topoIV	S. aureus	S.pneumoniae	H. influenzae
101	0.015	<0.004	0.046	0.063	0.008	1
102	0.016	<0.004	0.058	0.031	<0.008	0.25