Table 3.
Multivariate analysis investigating the association between cognitive function (outcome) and CPC subgroups
| Variable | CD34+ | CD34+/CXCR4+ | CD34+/VEGFR2+ | CD34+/CD146+ |
|---|---|---|---|---|
| β (95% Confidence Interval) | ||||
| Visual Memory | ||||
| Immediate | −0.13 (−0.44, 0.17) | 0.10 (−0.48, 0.69) | 1.2 (1.46, 3.21) | 3.06 (1.33, 4.79) |
| Delayed | −0.05 (−0.37, 0.26) | 0.36 (−0.23, 0.96) | 1.33 (0.17, 2.17) | 3.14 (1.38, 4.90) |
| Consolidation | 3.96 (−1.21, 6.33) | 2.84 (−0.23, 5.74) | 0.78 (0.12, 1.35) | 1.21 (−1.4, 1.85) |
| Verbal Memory | ||||
| Immediate | 0.10 (−0.11, 0.32) | 0.38 (−0.02, 0.79) | 1.14 (−8.35, 10.64) | 1.00 (−0.20, 2.23) |
| Delayed | 0.03 (−0.21, 0.28) | 0.35 (−0.11, 0.82) | 1.47 (0.41, 3.50) | 2.05 (0.66, 3.43) |
| Consolidation | 0.16 (−1.61, 1.87) | 1.18 (−1.57, 3.95) | 3.91 (1.42, 5.31) | 1.6 (0.36, 1.95) |
| Trail-A | 0.41 (−0.71, 1.54) | −0.08 (−2.27, 2.05) | 1.31 (−3.51, 6.30) | −3.42 (−9.61, 2.77) |
| Trail-B | 0.84 (−2.08, 3.71) | 0.18 (−5.35, 5.74) | 4.85 (−7.91, 17.52) | −8.02 (−24.5, 8.25) |
All subsets of CPCs are Log2 transformed, indicating that each unit increase in the Log2 CD34+ subgroup represents a doubling of cell count. All values expressed as β, and 95% confidence interval. Bolded numbers indicate a p-value of <0.012. A higher score in verbal and logical memory scales indicates a better cognitive function, while lower scores on the Trail-A and B tests indicate better cognitive function. All models were adjusted for demographic factors (age, sex, race/ethnicity, education), and cardiovascular risk factors and comorbidities (body mass index, glomerular filtration rate, hypertension, obesity, hyperlipidemia, diabetes, smoking, previous myocardial infarction, previous coronary artery bypass grafting, presence of angiographic atherosclerosis, left ventricular ejection fraction, history of a positive stress test, of heart failure, and of atrial fibrillation.