Table 3.

Thyroid function in NOD TPO-CRE-ER-BRAF^v600E mice according to the experimental group

		Serum TSH (pg/mL)			Serum total T4 (ng/mL)
	Mice (n)	Baseline	PTC diagnosis	P-value vs baseline	baseline	PTC diagnosis	P-value vs baseline
Concomitant IET
Tamoxifen	14	265 ± 248	15830 ± 12979	<0.001	161 ± 39	68 ± 49	<0.001
Corn oil	6	295 ± 202	893 ± 1472	0.347	164 ± 46	143 ± 52	0.476
Pre-existing IET
Tamoxifen	14	214 ± 113	679 ± 956	0.082	183 ± 47	182 ± 83	0.969
Corn oil	8	256 ± 93	645 ± 732	0.158	160 ± 103	157 ± 90	0.951
No IET
Tamoxifen	17	370 ± 332	9454 ± 11015	0.002	176 ± 44	107 ± 49	<0.001
Corn oil	17	411 ± 349	264 ± 267	0.002	180 ± 41	242 ± 113	0.041

Blood was collected at baseline and at the time ultrasonographic evidence of papillary thyroid cancer was first established

Abbreviations: IET, iodine exacerbated thyroiditis; PTC, papillary thyroid cancer; TSH, thyroid-stimulating hormone.