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. 2021 Jul 26;10(8):714. doi: 10.3390/biology10080714

Figure 3.

Figure 3

Mutation distribution over the open reading frame of DGAT2. (A) Cartoon of DGAT2 protein structure adapted from [7]. Residue numbers are inferred from the mouse data. The protein is predicted to cross the ER membrane once between amino acids 66–115 and bind (but not cross) the membrane two more times between 156–119 and 293–309. The amino acid sequence HPHG is conserved in the DGAT2 family proteins. The FLXLXXXn is a consensus sequence for lipid metabolizing proteins. (B) Frequency distribution of mutations that fall over the CDS of DGAT2. A D222B hotspot is identified in kidney cancers.