Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Jul 26;10(8):714. doi: 10.3390/biology10080714

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Model of the functional consequence in cancers linked to DGAT2 mutations. An initial DNA damage event on the sequence of DGAT2 occurs through various mechanisms. DGAT2 pathogenic mutations become fixed in cells that adapt and thrive in specific tissue environments. As the population of DGAT2 mutant cells outcompetes its wild-type counterparts, lipid metabolism changes due to altered function in the DGAT2 protein and associated lipid regulators. Cancer-promoting conditions select for DGAT2 deregulation to contribute to cellular transformation.