Table 2.

DGAT2 alleles with significant VEST values.

1 Mutation	2 VEST p-Value	2 VEST FDR	Tissue	3 dbSNP
G212C	0.00071000	0.05	CNS	rs777087960
H163R	0.00071000	0.05	Endometrium
R259H	0.00091000	0.05	Large Intestine
E243Q	0.00121000	0.05	Upper Aer Dig
F314S	0.00152000	0.05	Upper Aer Dig
P329S	0.00182000	0.05	Endometrium
F262V	0.00182000	0.05	Pancreas
G261C	0.00253000	0.05	Lung
G197D	0.00283000	0.05	Endometrium	rs369680804
S278F	0.00283000	0.05	Soft Tissue
G318R	0.00314000	0.05	Kidney
L267R	0.00314000	0.05	Liver
G164S	0.00536000	0.05	Haem and Lymph
P215H	0.00607000	0.05	Endometrium
G120D	0.008	0.10	Skin
R205K	0.0082	0.10	Lung
A241V	0.01002000	0.10	Lung	rs766238005
L245V	0.01113000	0.10	Lung
W100L	0.01214000	0.10	Skin
N155S	0.01295000	0.10	Skin
G270R	0.01326000	0.10	Lung
G167D	0.01427000	0.10	Prostate
P141S	0.01488000	0.10	Lung
S244C	0.01528000	0.10	Liver
K146N	0.0164	0.10	Large Intestine
R218W	0.01791000	0.10	Skin	rs528376420
A310T	0.01893000	0.10	CNS	rs761761542
W126R	0.02054000	0.10	Stomach
P215S	0.02146000	0.10	Skin
D222V	0.02257000	0.10	Kidney, Large intestine
N228Y	0.0248	0.10	Stomach
S294F	0.0249	0.10	Skin
R297Q	0.02844000	0.10	Haem and Lymph	rs140793537
R297 *	0.03186000	0.10	Stomach	rs771080849
Y139 *	0.03273000	0.10	Esophagus
R189L	0.0339	0.10	Skin
R137 *	0.03489000	0.10	Skin	rs572486802
4 Diagram with mutation distribution

¹ Only those mutations with significant VEST values are shown. Mutations are organized by p-value significance. ² Significance was chosen for mutations with p-value < 0.05 and FDR < 0.1. ³ NCBI Identifiers for mutations that have single nucleotide polymorphisms. ⁴ Green labels represent point mutations and black labels represent truncations.