Table 1.
Morphometrical analyses of MRI and anthropometric parameters during aging.
| Parameter | Wild-Type Mice | NLRP3-Knockout Mice | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Y | EA | EA + aMT | OA | OA + aMT | Y | EA | EA + aMT | OA | OA + aMT | |
| Heart length (cm) | 1.00 ± 0.02 |
0.99 ± 0.03 |
0.98 ± 0.03 |
0.86 ± 0.02 |
0.98 ± 0.02 |
1.03 ± 0.01 |
1.04 ± 0.05 |
1.2 ± 0.03 |
0.94 ± 0.01 |
0.99 ± 0.01 |
| Left ventricle lumen length (cm) | 0.6 ± 0.02 |
0.48 ± 0.01 |
0.53 ± 0.02 |
0.46 ± 0.02 |
0.59 ± 0.01 |
0.65 ± 0.01 |
0.62 ± 0.02 |
0.71 ± 0.02 |
0.51 ± 0.01 |
0.59 ± 0.02 |
| Left ventricle wall thickness (cm) | 0.12 ± 0.01 |
0.16 ± 0.008 |
0.13 ± 0.006 |
0.19 ± 0.008 |
0.14 ± 0.003 |
0.09 ± 0.006 |
0.13 ± 0.008 |
0.11 ± 0.005 |
0.14 ± 0.007 |
0.10 ± 0.007 |
| Body weight (g) | 20.07 ± 0.35 |
25.63 ± 0.66 |
26.93 ± 0.97 |
31.17 ± 0.84 |
32.17 ± 0.47 |
21.10 ± 0.92 |
30 ± 1.02 |
31.93 ± 1.14 |
33.27 ± 1.68 |
35.23 ± 0.87 |
| Heart weight (mg) | 120.8 ± 2.3 |
124.4 ± 1.7 |
142.9 ± 2.6 |
140.1 ± 2.2 |
165.3 ± 2.1 |
129.5 ± 2.5 |
148.4 ± 1.9 |
179.0 ± 2.3 |
161.9 ± 5.9 |
181.1 ± 2 |
| Heart weight/body weight (mg/g) | 6.02 ± 0.01 |
4.86 ± 0.13 |
5.32 ± 0.12 |
4.5 ± 0.05 |
5.14 ± 0.12 |
6.15 ± 0.23 |
4.96 ± 0.14 |
5.62 ± 0.15 |
4.88 ± 0.07 |
5.15 ± 0.08 |
Y, young, EA, early-aged; EA + aMT, early-aged with melatonin; OA, old-aged; OA + aMT, old-aged with melatonin.