Table 1.
Characteristics of the included studies.
| Author (Year) |
Country | Age | Participants (Female) |
Traceability (%) | Intervention | Evaluation Period | Outcomes in Diabetes |
Outcomes in Periodontitis |
||
|---|---|---|---|---|---|---|---|---|---|---|
| Exp | Cont | Exp | Cont | |||||||
| Anton et al. [53] (2021) |
Romania | 53.2±3.4 | 52.2±53 | 22 (16) | 22 (14) | 92 | 1. SRP + melatonin tab (3 mg) 2. SRP + placebo |
8 W | HbA1c, waist circumference; hip circumference; waist/hip ratio | PPD, CAL, BOP, PI |
| Kunsongkeit et al. [58] (2019) |
Thailand | 59.87 ± 11.3 | 57.94 ± 14.0 | 15 (11) | 16 (11) | 100 | 1. SRP + Vitamin C (500 mg) 2. SRP + placebo |
4, 8 W | FBS, HbA1c | PPD, CAL, PI, SBI |
| Bazyar et al. [54] (2019) |
Iran | 53.72 ± 6.68 | 51.45 ± 5.03 | 22 (16) | 22 (14) | 88 | 1. SRP + melatonin tab (3 mg) 2. SRP + placebo |
8 W | height, weight, BMI, waist circumference, hip circumference, waist/hip ratio, physical activity and serum levels of melatonin, IL-6, TNF-α and hc-CRP | PPD, CAL, BOP, PI |
| Javid et al. [61] (2018) |
Iran | 1. 57.75 ± 8.58 2. 57.88 ± 6.03 3. 53.14 ± 6.91 |
53.60 ± 6.23 | 1. 10 (5) 2. 9 (4) 3. 10 (8) |
12 (10) | 85 | 1. SRP + Omega-3 Fatty Acids (180 mg EPA and 120 mg DHA) 2. SRP + Cranberry Juice 3. SRP + Cranberry Juice + Omega-3 Fatty Acids 4. SRP |
8 W | Waist circumference, BMI, FBS, HbA1c | PPD |
| Javid et al. [57,60] (2017, 2019) |
Iran | 49.1 ± 7.4 | 50.9±8.9 | 22 (18) | 21 (16) | 86 | 1. SRP + resveratrol (480 mg/day) 2. SRP + placebo capsules |
4 W | FBG, Insulin, HOMA-IR, TG, Serum levels of IL6, TNFa and TAC | PPD, CAL |
| El-Sharkawy et al. [55] (2016) |
Egypt | 48.9 ± 8.3 | 51.2 ± 6.5 | 26 (9) | 24 (8) | 96 | 1. SRP + oral propolis (400 mg/day) 2. SRP + placebo |
3, 6 M | HbA1c, FPG, serum CML | PPD, CAL, BOP, PI, Eastman interdental bleeding index (EIBI) |
| Pradeep et al. [59] (2016) |
India | 35.03 ± 4.78 | 34.76 ± 5.57 | 30 (14) | 30 (13) | 100 | 1. SRP + locally Aloe vera gel 2. SRP + placebo gel |
3, 6 M | N/A | PPD, PI, mSBI, CAL |
| Gokhale et al. [56] (2013) |
India | 30–60 | 30–60 | 15 | 15 | 100 | 1. SRP + ascorbic acid (450 mg) 2. SRP + placebo candy |
2 W | N/A | PPD, PI, SBI |
SRP, scaling and root planing; PPD, periodontal pocket depth; CAL, clinical attachment loss; BOP, bleeding on probing; PI, plaque index; GI, gingival index; SBI, sulcus bleeding index; EIBI, Eastman interdental bleeding index; mSBI, modified sulcus bleeding index; HbA1c, Hemoglobin A1C; FBS, fasting blood sugar; BMI, body mass index; HOMA-IR, homeostatic model assessment for insulin resistance; FBG, fasting blood glucose; TG, triglyceride; TAC, total antioxidant capacity; FPG, fasting plasma glucose; CML, Nε-(carboxymethyl) lysine.