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. 2021 Aug 13;10(8):1284. doi: 10.3390/antiox10081284

Figure 2.

Figure 2

Loss of primary cilia in DA neurons results in decreased striatonigral integrity. (A,B). Representative confocal images of coronal striatal sections showing TH immunoreactivity (green) and (D,E) DAT immunoreactivity (red) in control and Ift88 cKO mice at 1 month. (C,F) Analysis of TH and DAT fluorescence mean intensities in control and Ift88 cKO dorsal striatum at 1 and 6 months (n = 3 mice per group). (G) Quantification of dopamine (in figure abbreviated as DA for simplicity), its major metabolites (DOPAC, HVA, 3-MT), and other monoamines (NA, 5-HT) in the striatum of control and Ift88 cKO mice by HPLC-EC at 6 months (n = 9 controls, n = 5 Ift88 cKO). The data are presented as the mean ± SEM. Statistical significance between the indicated groups determined by unpaired two-tailed Student’s t-test, * p < 0.05 (for details, see also supplementary statistical information). Abbreviations: str, striatum; cx, cortex. Scale bar, 100 μm.