Figure 6.

The length of PC increases during aging in striatal neurons of wildtype mice, but not in DA neurons. (A,B,D–H) Representative confocal images of coronal sections showing ACIII in striatal and SN and VTA DA neurons by immunofluorescence with an ACIII-specific antibody (green) and a TH-specific antibody (red) at 1 month and at 1 year. Quantification of the average PC length in striatal neurons of control mice (C) and in SN and VTA DA neurons (F,I) at 1 month and 1 year. At least 80 cilia from each mouse were measured (n = 3 per group). The data are presented as the mean ± SEM. Statistical significance between the indicated groups was determined by unpaired two-tailed Student’s t-test; * p < 0.05, *** p < 0.0005 (for details, see also supplementary statistical information). Scale bars: (A,C): 25 μm; (B,D): 50 μm.