Table 2.

Go enrichment analysis of mRNAs in closed groups (30d vs. 90d, 30d vs. 150d, and 30d vs. 210d).

Groups	mRNAs	lncRNAs
30d vs. 90d (upregulated)	-Tissue and organ morphology development -Epithelial and endothelial cell proliferation -Extracellular matrix -Cell adhesion -Calcium ion binding	-Zinc ion binding -Transition metal element ion binding -Transcription factor complex -Steroid hormone receptor activity
30d vs. 150d (upregulated)	-Cell link assembly regulation -Smooth muscle cell proliferation regulation -Negative feedback regulation of angiogenesis -Collagen fiber tissue development -Protein folding	-Transcription factor complex -Ligand activated transcription factor activity -Steroid hormone receptor activity -Thyroid hormone-mediated signaling pathway -Nuclear receptor activity
30d vs. 210d (upregulated)	-Endothelial cell proliferation -Negative regulation of vascular development -Regulation of cell junction assembly -Collagen fiber tissue -Adsorption of cells and substrates	-Lipid biosynthesis regulation -Fatty acid oxidation regulation -Fatty acid metabolism regulation -Acyl-CoA biosynthesis -Male gonadal development -Ion homeostasis
30d vs. 90d (downregulated)	-Steroid dehydrogenase activity -Steroid metabolism -RNA-guided DNA polymerase activity -Organic acid biosynthesis -Cellular amino acid metabolism -Catalytic activity on DNA	-Catalytic activity -Hydrolase activity -Myosin filaments -Myosin complex
30d vs. 150d (downregulated)	-Steroid hydroxylase and dehydrogenase activity -Cholesterol reversal transport -Lipoprotein complex -Lipoprotein particles	-DNA packaging complex -Protein-DNA complex -Nucleosome -Protein heterodimerization activity -21-carbon steroid hormone metabolism -Androgen dehydrogenase activity -Ketosteroid monooxygenase activity
30d vs. 210d (downregulated)	-Triglyceride homeostasis -Sterol biosynthesis and transport -High-density lipoprotein particles -Dihydroxy acid metabolism process	-Protein-DNA complex -Protein heterodimerization activity -Nucleosome