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. 2021 Jul 29;10(8):726. doi: 10.3390/biology10080726

Table 3.

Go enrichment analysis of mRNAs in consecutive groups (30d vs. 90d, 90d vs. 150d, and 150d vs. 210d).

Groups mRNAs lncRNAs
30d vs. 90d (upregulated) -Tissue and organ morphology development
-Epithelial and endothelial cell proliferation
-Extracellular matrix
-Cell adhesion
-Calcium ion binding
-Zinc ion binding
-Transition metal element ion binding
-Transcription factor complex
-Steroid hormone receptor activity
90d vs. 150d (upregulated) -Protein folding
-Chaperone-mediated protein folding
-RNA binding
-Positive regulation of epithelial cell -proliferation
-Male gonadal development
-Cell response to peptides
150d vs. 210d (upregulated) -Sterol homeostasis and transport,
-Lipoprotein particles,
-High-density lipoprotein particles,
-Cholesterol homeostasis and transport activity
-Transferase activity
-DNA polymerase activity
-Nucleotide transaminase activity
-Nuclease activity
-Endonuclease activity
-Hydrolase activity acting on ester bonds
30d vs. 90d (downregulated) -Steroid dehydrogenase activity
-Steroid metabolism
-RNA-guided DNA polymerase activity
-Organic acid biosynthesis
-Cellular amino acid metabolism
-Catalytic activity on DNA
-Catalytic activity
-Hydrolase activity
-Myosin filaments
-Myosin complex
90d vs. 150d (downregulated) -Transferase activity
-DNA polymerase activity
-Nuclease activity
-Nucleotide transferase activity
-Hydrolase activity acting on ester bonds
-Steroid dehydrogenase activity
-Protein-DNA complexes
-Protein heterodimers and dimer activity
-Nucleosomes
-DNA packaging complexes and chromatin parts
150d vs. 210d (downregulated) -Protein folding
-Chaperone-mediated protein folding
-Protein stability regulation
-Thyroid development
-Signal pathway mediated by thyroid hormone
-Negative regulation of transcription initiation by RNA polymerase II promoter