Table 1.
Gamma oscillations in AD mouse models.
| Mouse Model | Age (Months) | Sex | Preparation | Frequency Band (Hz) | Changes in γ Oscillations | Reference |
|---|---|---|---|---|---|---|
| APP/PS1 | 4–5 | NA | EC slices | 20–60 | Reduced γ frequency in LEC No effect in MEC |
[139] |
| J20 | 4–7 | M/F | in vivo cEEG | 20–80 | Reduced γ power | [140] |
| 7–8 | M/F | in vivo cEEG | 30–90 | Reduced γ power | [141] | |
| 5xFAD | 3 | M | in vivo LFP in CA1 | 20–50 | Reduced γ power during SWRs | [89] |
| TgCRND8 | 1 | NA | HC slices | θ: 3–12 low γ: 25–85 high γ: 120–250 |
No change in γ power Disrupted θ–γ coupling |
[142] |
| 1 | M | in vivo HC LFP | low γ: 25–45 high γ: 60–100 |
Reduced γ power | [143] | |
| APOE4 | 5–17 | F | in vivo HC LFP | 30–50 | Reduced γ power | [144] |
| 4–5 | F | in vivo HC LFP | 30–50 | Reduced γ power during SWRs | [145] | |
| 3R tau overexpression | 7 | M | HC slices | 50–90 | Reduced γ power and peak frequency | [146] |
cEEG, cortical EEG. EC, entorhinal cortex. HC, hippocampus. LFP, local field potential. LEC, lateral EC. MEC, medial EC. SWR, sharp wave-ripple.