Table 3.
Slow and delta oscillations in AD mouse models.
| Mouse Model | Age (Months) | Sex | Frequency Band (Hz) | Changes in Oscillations | Reference |
|---|---|---|---|---|---|
| 3xTg-AD | 7, 20 | M/F | <1 | Increased frequency at 7 months Decreased frequency at 20 months More irregular at 20 months |
[233] |
| 3xTg-AD | 18 | M/F | 0.1–4 | No change | [234] |
| APP/PS1 | 8–10 | M/F | 0.1–4 | Decreased power during NREM | |
| Tg2576 | 12 | M/F | 0.1–4 | Decreased power during W | |
| Tg2576 | 2, 6, 12 | NA | 0.5–4 | Decreased power during NREM at 6–12 months | [236] |
| APP/PS1 | 3, 6, 9 | NA | >1 | Shorter NREM at 9 months | [235] |
| P301S | 3–12 | M | 1–4 | Increased power during NREM at 6–9 months Decreased power during W and NREM at 11 months |
[237] |
| rTg4510 | 5–10 | M | 0.1–4 | Decreased power during NREM from 6 months | [238] |
| PLB1triple | 5–21 | M/F | 0.5–5 | Decreased power during REM at 9 months Decreased power during W at 21 months |
[239] |
| PLB2tau | 6 | F | 1.5–5 | Increased power during REM Decreased power during NREM |
[240] |
REM, rapid eye movement sleep. NREM, non-REM sleep. W, wakefulness.