Fig 2. Age-stratified odds-ratios for combined genetic risk scores.

(A-F) Age-stratified odds ratios in held-out testing data for genetic risk scores for six disorders where there is evidence for a single non-constant genetic risk profile, “Primary (essential) hypertension” (ICD-10 code I10), “pure hypercholesterolaemia” (E78.0); “Calculus of gallbladder without cholecystitis” (K80.2) and “Hypothyroidism, unspecified” (E03.9); “atherosclerotic heart disease of native coronary artery” (I25.1) and “other and unspecified malignant neoplasm of skin and unspecified parts of face” (C44.3). Results for all diseases are shown in S1 Fig. Odds ratios for the 80th (blue) and 90th percentiles of a combined genetic risk score within matched case-control samples (four controls for each case) are shown for each age interval; points indicate the average odds ratio of twenty five-fold cross-validation analyses with lines indicating the 95% confidence interval.