Fig 4. Systemic and local inflammatory responses to infection.

IFNγ, TNFα, IL-6, IL-12-p70, KC/GRO (CXCL-1) and IL-2 levels were assessed in the plasma (A) or in the media of iBAT (B) and scWAT (C) explants from mice that were treated for 1 week with CL316,243 daily (1 mg/kg/day) or vehicle only (NaCl), and infected with E. coli for 48 hours. The results are displayed as independent values (dots) and the mean ± SD. n = 8 (plasma) or 4 (explants). * p<0.05.