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. 2021 Aug 26;17(8):e1009800. doi: 10.1371/journal.ppat.1009800

Fig 7. ISRE-luciferase promotor activation inhibition by SARS-CoV-2 genes.

Fig 7

HEK-293T cells were transfected with pRL-TK (Renilla normalization control vector), pISRE-luciferase and viral plasmids to express the indicated viral protein or empty pUC-18 vector. The rabies virus phospho-protein–RABVP1 served as positive control. 24 hours post transfection cells were treated for 8 hours with 1000U/ml IFNα before cells were lysed and analysed by dual luciferase assay. Data shown are of the ratio of IFN-treated / untreated cells calculated from normalised luciferase activity (Firefly/Renilla) for each given viral gene. The data (average values ± SEM) is representative of three independent experiments.