Table 1. Summary of Aspergillus fumigatus genes discussed in this review.

Gene name	AF293 Gene ID	Function	Reference(s)
gprK	Afu4g01350	Mediates germination in response to carbon sources. Null mutants have increased germination in the absence of carbon	[26]
sfaD gpgA	Afu5g12210 Afu1g05210	GPCR subunits, null mutants have delayed germination	[23]
sakA	Afu1g12940	A. fumigatus HOG1 homolog. Induced in response to nitrogen starvation, null mutants have increased germination with poor nitrogen sources, null mutants have decreased adhesion	[29,71]
srbA	Afu2g01260	Hypoxia responsive bHLH transcription factor essential for growth in low oxygen. Regulates sterol synthesis genes, has a role in polarity, and is required for biofilm structure and maturation	[31,86,88,14]
pkac1 pkac2	Afu2g12200 Afu5g08570	Protein kinases that regulate oxidative metabolism. Null mutants have reduced germination	[32]
rasA	Afu5g11230	Regulates stages of conidial germination in response to carbon sources	[40]
crzA	Afu1g06900	Mediator of calcineurin signaling null mutants have reduced germination	[41]
calA	Afu3g09690	Binds host integrin to facilitate invasion of host tissue	[55,56]
uge3	Afu3g07910	UDP-glucose epimerase required for GAG synthesis. Null mutants are unable to adhere to abiotic surfaces and exhibit reduced adherence to epithelial cells	[66]
medA	Afu2g13260	Transcription factor that regulates GAG biosynthetic cluster. Null mutants have reduced uge3 expression and reduced adhesion	[67]
stuA	Afu2g07900	Transcription factor that regulates GAG biosynthetic cluster. Null mutants have reduced uge3 expression and reduced adhesion	[67]
somA	Afu7g02260	Transcription factor, upstream regulator of medA and stuA. Role in GAG biosynthesis regulation. Null mutants have decreased adherence	[68]
mpkA	Afu4g13720	MAP kinase, null mutants have decreased adherence, cell wall integrity	[71]
sitA	Afu6g11470	MpkA-regulating phosphatase, upstream regulator of mpkA in coordinating surface adhesion and cell wall composition	[72]
mdr4	Afu1g12690	Multidrug resistance pump up-regulated in maturing biofilms	[79]
cdr1B	Afu1g14330	Putative drug efflux pump	[81]
atrR	Afu2g02690	Transcription factor, regulates cdr1B expression. Null mutants have significantly reduced expression of cdr1B. Low oxygen growth defect	[81]
cyp51A	Afu4g06890	14-α sterol demethylase, null mutants have increased azole sensitivity	[85]
bafA	Afu5g14915	Cryptic gene sufficient to induce hypoxia morphology	[95]