Table 6. Residues with the Highest Contributions to the C8_DEDs–cFLIP_DEDs Binding Affinity Identified by Alanine Scanning Calculations^a.

mutation in C8	ΔAff kcal mol–1	mutation in cFLIP	ΔAff kcal mol–1
F122A	12.0	R45A	10.8
R118A	7.9	R47A	9.3
Q125A	5.1	L41A	5.5
		D39A	5.3

^aOnly mutated residues with ΔAff > 5 kcal mol^–1 are listed.