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Hypomethylation of global DNA (a) and alterations in gene specific methylation of Pparg (b) after hypoxia or ischemia and exposure to amorfrutin B (5 μM). The results are presented as a mean ± SEM. There were 3 independent experiments, consisting of 6 replicates per group. * p < 0.05, ** p < 0.01, and *** p < 0.001 compared to the control group, ### p < 0.001 compared to the cultures exposed to hypoxia, ^^^ p < 0.001 compared to the cultures exposed to ischemia.
