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General structures of NF-κB and IκB proteins. Shown are the general structures of human NF-κB and Rel proteins, as well as IκB proteins (i.e., IκBα, IκBβ, IκBε, BCL3). RHD, Rel homology domain; NLS, nuclear localization sequence; GRR, glycine-rich region; ANK, ankyrin repeats (black bars). The details of the indicated protein domains are described in the text.
