Table 3.
Some cancer-relevant biological processes and relevant target genes controlled by NF-κB.
| Biological Process | Relevant Target Genes | Ref. |
|---|---|---|
| Cell survival (antiapoptosis) | BCL2, BCLXL, IAPs | [68] |
| Cell cycle | CCND1, CD44, CDK2, CDKN1A | [80] |
| Metastasis | MMP2, MMP9, UPA, SOX9 | [101] |
| Angiogenesis | IL-1β, IL-8, MMP9, VEGF-A, FASL | [102] |
| Epithelial-to-mesenchymal transition | TWIST1, SLUG, SIP1, SNAIL | [94,103] |
| Inflammation | CXCL8, IL-6, TNFA, IL-1β, iNOS, COX2 | [85] |
| Immortalization | TERT, EZH2 | [104] |
| Senescence | IL-6, TNFA, IL-1β | [105] |
| Energy metabolism | GLUT3, SCO2 | [106] |
| T cell inhibition | FOXP3, PDCD1 | [107] |
| Cancer stem cells | NANOG, SOX2, CD44, KLF4 | [101] |