Table 1.
Articles collected and analyzed.
| Author | Year | Type of Study | N Patients | Comorbidities | Objective | Outcome |
|---|---|---|---|---|---|---|
| Ali Faghih Habibi, Hooshang Gerami, et al. | 2019 | Case-Control Study | 117 | compare serum level of 25-OH-VitD in CRSw/sNP patients and control groups | serum 25-OH-VitD was significantly lower in CRS patients | |
| Ankur Kumar Chandrakar, Arun Alexander et al. | 2014 | cross-sectional study | 80 patients with nasal polyposis and 80 healthy subjects | Atopy | Assessment of the levels of 25-hydroxy vitamin D and high sensitivity C-reactive protein (hs-CRP) in patients with nasal polyposis and control subjects, and identified their association with disease severity in nasal polyposis. | The severity of polyposis correlated negatively with serum levels of 25-hydroxy vitamin D and positively with hs-CRP |
| Anna Bonanno, Sebastiano Gangemi et al. | 2014 | Case-control study | 28 controls (HC), 11 allergic rhinitis (AR) patients, and 35 allergic asthma with rhinitis (AAR) patients | Allergy and asthma | whether low vitamin D is linked with circulating IL-31 and IL-33 in children with allergic disease of the airways | low levels of 25(OH) Vit D might represent a risk factor for the development of concomitant asthma and rhinitis in children with allergic disease of the airways independently of IL-31/IL-33 Th2 activity |
| Arash Shahangian, Rodney J.Schlosser | 2016 | Review | 0 | Explore some of the contributions of VD3 to chronic rhinosinusitis with nasal polyposis and its role as a disease-modifying agent | There is likely a role for VD3 use as a disease-modifying agent in treatment of patients with recalcitrant CRSwNP | |
| B Rostkowska-Nadolska, E Sliupkas-Dyrda et al. | 2010 | investigate the influence of calcitriol and tacalcitol on the secretion of IL-6 and IL-8 by fibroblasts derived from NP | Calcitriol and tacalcitol are capable of affecting pro-inflammatory cytokine (IL-6 and IL-8) levels in NP cultures | |||
| Badr El-Din Mostafa, Mohammed Shehata Taha et al. | 2016 | Case-control study | 74 | Measure VD3 levels in patients with AFRS and chronic rhinosinusitis (CRS) | Serum level of VD3 in patients with CRSwNP and AFRS is significantly lower than that of patients with CRSsNP and control subjects | |
| Binayak Baruah, Ajay Gupta et al. | 2020 | retrospective 1-year study | 200 | Comparison of incidence of vitamin D deficiency in CRS patients to normal population and evaluation of the beneficial role of its supplementation in treatment | Higher prevalence of vitamin D deficiency in CRS patients and that vitamin D supplementation went a long way in alleviating their symptoms | |
| Bo Li, Miaowei Wang et al. | 2021 | meta-analysis | 337 chronic rhinosinusitis patients and 179 healthy controls | asthma and/or atopic status |
Compare the serum vitamin D levels between patients with chronic rhinosinusitis and healthy controls and evaluate the associations of vitamin D level with its occurrence | Detection of a significant association between lower serum vitamin D status and chronic rhinosinusitis, especially in chronic rhinosinusitis with nasal polyps patients |
| E Ritter Sansoni, Nathan B Sautter et al. | 2015 | Case-control study | 57 (CRSsNP (n = 31), CRSwNP (n = 14), and controls (n = 12)) | Correlation between 25-VD3 levels and sinonasal mucus monocyte chemoattractant protein-1 (MCP-1), regulated upon activation normal T cell expressed and secreted (RANTES), and basic fibroblast growth factor (bFGF) levels in patients with CRS | 25-VD3 may play a role in regulation of RANTES and bFGF expression in CRSwNP. This may occur through regulation of NP fibroblasts or other immune cells | |
| F Bavi, R Movahed, M Salehi, et al. | 2019 | cross-sectional study | 166 cases with CRSwNP and 172 healthy subjects | Serum vitamin D3 levels in patients with CRSwNP and its association with disease severity | Disease severity, based on imaging, endoscopic and clinical criteria, was inversely associated with serum vitamin D levels | |
| Farnaz Hashemian, Sonya Sadegh, et al. | 2020 | triple-blind placebocontrolled clinical trial |
Investigate the effects of oral VD3 on the recurrence of polyposis after FESS | Efficacy and safety of vitamin D supplementation in the reduction of polyposis recurrence after FESS in patients with CRSwNP | ||
| Feng Wang, Yang Yang, Haihong Chen | 2019 | Retrospective analysis of collected data |
Atopic status and asthma | Serum vitamin D level in patients with chronic rhinosinusitis with nasal polyps and its correlation with the disease severity | Serum 25-hydroxyvitamin D3 levels are lower in Chinese CRSwNP patients. These 25-hydroxyvitamin D3 levels are associated with SNOT-22 score. Preoperative 25-hydroxyvitamin D3 level may impact the symptom improvement after surgery | |
| Iordanis Konstantinidis, Maria Fotoulaki et al. | 2017 | Case-control study | 152 adult participants were included in five phenotypic groups: CF with NP (CFwNP) (n = 27), CF without NP (CFsNP) (n = 31), CRS with NP (CRSwNP) (n = 32), CRS without NP (CRSsNP) (n = 30), and controls (n = 32) | Investigate if deficiency of VD3 is associated with the presence of NP in patients with cystic fibrosis (CF) and patients with chronic rhinosinusitis (CRS) | VD3 deficiency seemed to be associated with the presence of nasal polyps in the patients with CRS and in the patients with CF in a similar manner | |
| Jenna M Christensen, Jasmine Cheng et al. | 2017 | cross-sectional study | 31 patients (8 CRSsNP, 10 CRSwNP, and 13 controls) | Determine expression of genes encoding the vitamin D receptor (VDR), 25-hydroxylase (CYP2R1), 1α-hydroxylase (CYP27B1), and 24-hydroxylase (CYP24A1) | Vitamin D may be dysregulated at multiple levels, with decreased transcription of the metabolic gene CYP27B1 and increased transcription of the catabolic gene CYP24A1 observed | |
| Jennifer K Mulligan, Whitney N Pasquini et al. | 2017 | Observational studies | Impact of VD3 deficiency on inflammation and VD3 metabolism in an Aspergillus fumigatus (Af) mouse model of chronic rhinosinusitis (Af-CRS) |
VD3 deficiency causes changes in sinonasal immunity. Both VD3 deficiency and Af-CRS were associated with reductions in local levels of the active VD3 metabolite even with adequate circulating levels | ||
| Ling-Feng Wang, Chih-Feng Tai et al. | 2015 | Observational study | Understand the role of vitamin D in chronic rhinosinusitis with nasal polyps (CRSwNP) by investigating its effect on the secretion of matrix metalloproteinase-2 (MMP-2) and MMP-9 | Vitamin D derivatives could significantly inhibit TNF-α-induced MMP-2 and MMP-9 secretion in nasal polyp-derived fibroblasts | ||
| Ling-Feng Wang, Chih-Hung Lee et al. | 2013 | Case-control study | Determine if serum Vitamin D level is lower in chronic rhinosinusitis with nasal polyposis (CRSwNP) patients and if low serum Vitamin D level is correlated with the severity of CRSwNP | A significantly lower vitamin D level was found in a group of Taiwanese CRSwNP patients, which revealed an association with greater nasal polyp size | ||
| Malgorzata Tomaszewska, Elzbieta Sarnowska et al. | 2019 | Case-control study | 52 patients with CRS without nasal polyps (sNP), 55 with CRS with nasal polyps (wNP), and 59 in the control group | Atopy | Relationships between the total concentration of vitamin D, vitamin D receptor (VDR) expression, 1α-hydroxylase expression, and clinical data, including age, gender, Sino-Nasal Outcome Test (SNOT-22), computerized tomography (CT) scan, allergy status, and vitamin D supplementation in CRS patients with (CRSwNP) and without nasal polyps (CRSsNP), and in a control group | vitamin D and its receptor and enzymes may play a role in CRS |
| Murdaca, G., Tonacci, A. et al. | 2019 | update | Find a correlation between vitamin D levels and its effect upon several autoimmune diseases | Inverse association between vitamin D and the development of several autoimmune diseases | ||
| Omer Erdag, Mahfuz Turan, et al. | 2016 | case-control study | 46 subjects with NP (NP group) and 40 volunteers (control group) | Assess the relation between levels of vitamin D receptor (VDR) gene expression and serum vitamin D with NP | VDR gene expression may be associated with the pathogenesis or progression of NP | |
| Patrick J Stokes, Joanne Rimmer | 2016 | systematic review | 539 | asthma and/or atopic status |
Relationship among serum VD3 levels, CRS phenotype, and disease severity by using outcome assessments | Significantly lower VD3 levels in the polypoid phenotypes of CRS compared with controls. Low VD3 levels were often associated with an increased degree of inflammation |
| Pooja Thakur, Praneeth Potluri | 2020 | prospective casecontrol study | Evaluate the association of serum vitamin D levels with chronic rhinosinusitis (CRS) in population residing at high altitudes and to assess its correlation with severity of CRS | Lower vitamin D level is associated with CRS, irrespective of presence or absence of nasal polyposis in adults residing at high altitudes. Vitamin D is an independent predictive factor for CRS. There is an inverse moderate correlation of severity of CRS with vitamin D | ||
| Rodney J. Schlosser, Zachary M. Soler, et al. | 2014 | Retrospective review | Determine if CRSwNP populations are at risk for vitamin D3 (VD3) deficiency and if VD3 levels correlate with radiographic measures of disease severity or eosinophilia | VD3 insufficiency/deficiency is common in CRSwNP patients, especially those of African American race. Lower levels of VD3 are associated with worse LMS on CT | ||
| Sule Ozkara, Erol Keles, Nevin Ilhan et al. | 2012 | case-control study | 60 adult patients and 40 healthy volunteers | Allergic rhinitis | Study Th1/Th2 cell balance by measuring the levels of cytokines IL-4, IL-10, and IFN-γ and determine the correlation between Th1/Th2 cell balance and 1α,25-dihydroxyvitamin D(3) | vitamin D is effective on Th1/Th2 balance in patients with allergic rhinitis and that there is a significant relation between vitamin D deficiency and allergy |
| Vahid Zand, Mohammadhossein Baradaranfar et al. | 2020 | cross-sectional study | 93 patients suffering from chronic rhino sinusitis with nasal polyposis (CRS w NP) | Investigate the association between the serum vitamin D levels and severity of disease in chronic rhino sinusitis (CRS) patients | There was a significant relationship between the serum vitamin D levels and severity of disease in patients with CRS w NP | |
| William W Carroll, Rodney J Schlosser et al. | 2016 | Case-control study | 15 patients with CRSwNP and 12 control subjects | Investigate VD3 deficiency and HSNF proliferation in CRSwNP | VD3 deficiency is associated with increased HSNF proliferation in CRSwNP |