. 2021 Aug 1;10(8):735. doi: 10.3390/biology10080735

Table 4.

Analysis of iTNF-α, CD4+ lymphocytes, CD8+ lymphocytes, CD4+/CD8+ lymphocytes ratio, and Tregs at different time points. Mean, deviation standard, and p-value at first observation, between the first and third observation, and from the fourth observation onwards among good prognosis and exitus patients. The significant p-values are shown in bold.

Parameter	Determination Points	Mean ± SD	p-Value
iTNF-α %	1st Observation (Good Prognosis)	65.429 ± 11.914	0.469
	1st Observation (Exitus)	69.200 ± 13.570	0.469
	1st–3rd Day (Good Prognosis)	58.111 ± 12.6207	0.432
	After 4th Day (Good Prognosis)	64.167 ± 10.9450	0.432
	1st–3rd Day (Exitus)	67.467 ± 10.2878	0.0046
	After 4th Day (Exitus)	53.357 ± 14.1073	0.0046
CD4+ (cells/µL)	1st Observation (Good Prognosis)	367 ± 426	0.758
	1st Observation (Exitus)	334 ± 291	0.758
	1st–3rd Day (Good Prognosis)	431 ± 383	0.045
	After 4th Day (Good Prognosis)	561 ± 288	0.045
	1st–3rd Day (Exitus)	363 ± 162	0.748
	After 4th Day (Exitus)	334 ± 91	0.748
CD8+ (cells/µL)	1st Observation (Good Prognosis)	109 ± 47	0.0085
	1st Observation (Exitus)	204 ± 54	0.0085
	1st–3rd Day (Good Prognosis)	121 ± 51	0.0017
	After 4th day (Good Prognosis)	228 ± 126	0.0017
	1st–3rd Day (Exitus)	181 ± 67	0.151
	After 4th Day (Exitus)	160 ± 57	0.151
Ratio CD4+/CD8+	1st Observation (Good Prognosis)	3.25 ± 0.85	0.0026
	1st Observation (Exitus)	1.61 ± 0.37	0.0026
	1st–3rd Day (Good Prognosis)	3.26 ± 1.39	0.0209
	After 4th Day (Good Prognosis)	2.87 ± 0.63	0.0209
	1st–3rd day (Exitus)	2.16 ± 0.95	0.349
	After 4th Day (Exitus)	2.28 ± 0.88	0.349
Tregs (cells/µL)	1st Observation (Good Prognosis)	4.83 ± 1.89	0.884
	1st Observation (Exitus)	4.92 ± 1.58	0.884
	1st–3rd Day (Good Prognosis)	4.92 ± 2.35	0.0429
	After 4th Day (Good Prognosis)	6.79 ± 1.55	0.0429
	1st–3rd Day (Exitus)	4.75 ± 2.22	0.0426
	After 4th Day (Exitus)	3.75 ± 1.65	0.0426