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Effect of GZM extract on SIRT1/Nrf2 expression. GZM extract upregulated the expression of the SIRT1 (a) and Nrf2 proteins (b) in Neuro-2a cells. The expression levels of candidate antioxidant genes were increased after treatment with GZM extract in HT22 (c) and Neuro-2a (d) cells. (n = 3; * p < 0.05, ** p < 0.01, *** p < 0.001, and **** p < 0.0001, DMSO control vs. GZM extract treatment) The details of statistical values are provided in Table S6 (Supplementary Materials).
