Table 1. CDC Case Definition for MIS-C⁸.

• Age < 21 years      • Fever > 38oC or subjective fever > 24 hours      • Clinically severe illness requiring hospitalization with >2 organ involvement:           cardiac, renal, respiratory, hematologic, gastrointestinal, dermatologic or neurological      • Laboratory evidence of inflammation:           Elevated CRP, ESR, fibrinogen, procalcitonin, d-dimer, ferritin, LDH, IL-6, elevated neutrophils, reduced lymphocytes and low albumin      • No alternative plausible diagnoses      • Positive for current or recent SARS-CoV-2 infection by RT-PCR, serology or antigen test; or COVID-19 exposure within the 4 weeks prior to the onset of symptoms

CDC: Center for Disease Control; MIS-C: Multisystem Inflammatory Syndrome in Children; CRP: C-reactive protein; ESR: Erythrocyte Sedimentation Rate; LDH: lactic acid dehydrogenase; IL-6: Interleukin-6; RT-PCR: real time polymerase chain reaction; COVID-19: coronavirus disease 2019