Table 2. WHO Preliminary case definition for MIS-C⁹.

• Age 0-19 years      • Fever > 3 days      • AND 2 of the following:      1) Rash or bilateral non-purulent conjunctivitis or muco-cutaneous inflammation signs (oral, hands or feet)      2) Hypotension or shock      3) Features of myocardial dysfunction, pericarditis, valvulitis, or coronary abnormalities (including ECHO findings or elevated Troponin/NT-proBNP)      4) Evidence of coagulopathy (by PT, PTT, elevated d-Dimers)      5) Acute gastrointestinal problems (diarrhea, vomiting, or abdominal pain).      • AND           Elevated markers of inflammation such as ESR, CRP, or procalcitonin      • AND           No other obvious microbial cause of inflammation, including bacterial sepsis, staphylococcal or streptococcal shock syndromes.      • AND           Evidence of COVID-19 (RT-PCR, antigen test or serology positive), or likely contact with patients with COVID-19

WHO: World Health Organization; MIS-C: multisystem inflammatory syndrome in children; ECHO: echocardiogram ; PT: prothrombin time; PTT: partial prothrombin time; ESR: erythrocyte sedimentation rate; CRP: C-reactive protein; NT-proBNP: N-Terminal prohormone brain natriuretic peptide; RT-PCR: real-time polymerase chain reaction; COVID-19: Coronavirus disease 2019