Table 1. Overview of ABHD Proteins: Main Expression Pattern in Humans and Substrates of Each Protein Are Reported.

ABHD protein	main expression pattern	main substrates
ABHD1	testis	–a
ABHD2	ubiquitous expression, liver, stomach	triacylglycerols, esters
ABHD3	appendix, colon, gall bladder, lymph nodes, stomach, thyroid, small intestine, duodenum	medium-chain phospholipids, phosphatidylcholines containing C14 acyl chain, oxidatively truncated phospholipids
ABHD4	testis, gall bladder	–a
ABHD5	bone marrow, fat, skin	arachidonoyl-CoA, oleoyl-CoA, 1-oleoyl-lysophosphatidic, triacylglycerols
ABHD6	small intestine, duodenum, spleen, brain, brown adipose tissue, kidney, liver, skin, ovary	diacylglycerols, 1(3)-monoacylglycerols with saturated medium or long acyl chains, 2-arachidonoylglycerol, lysophosphatidylinositols, bis(monoacylglycero)phosphate
ABHD7	brain	–a
ABHD8	brain, testis	–a
ABHD9	skin, esophagus	epoxyeicosatrienoic acids, 9,10-epoxyoctadecamonoenoic acids, leukotoxin, linoleate-derived epoxy-alcohols
ABHD10	kidney, thyroid	S-palmitoyl substrates
ABHD11	skeletal muscle, colon, prostate, small intestine, thyroid	triacylglycerols, 2-oxoglutarate
ABHD12	ubiquitous expression, brain	2-arachidonoylglycerol, 1(3)-isomer of arachidonoylglycerol, unsaturated C20:4 monoacylglycerols, lysophosphatidylserine lipids
ABHD12B	skin	–a
ABHD13	ubiquitous expression	–a
ABHD14A	adrenal glands, brain, kidney, thyroid	–a
ABHD14B	ubiquitous expression	p-nitrophenyl butyrate
ABHD15	fat, liver	–a
ABHD16A	ubiquitous expression, skeletal muscle, brain and platelets	medium-chain saturated monoacylglycerols, 1-linoleylglycerol, 15-deoxy-Δ12,14-prostaglandin J2-2-glycerol ester
ABHD16B	testis	–a
ABHD17A	bone marrow, fat, lung, skin, spleen	S-palmitoyl-l-cysteine residue
ABHD17B	brain	S-palmitoyl-l-cysteine residue
ABHD17C	colon, esophagus, stomach, small intestine, brain, duodenum, lung, prostate, urinary bladder	S-palmitoyl-l-cysteine residue
ABHD18	ubiquitous expression	–a

^aNot determined.