| Reference |
Year |
Study type |
Sample size |
Population |
Follow-up time (mo) |
Outcome(s) |
| Ames et al. [20] |
2021 |
Metanalysis, randomized controlled trials |
92 |
Adults |
variable |
Vitamin D supplements lead to significant reductions in the rate of asthma exacerbations in participants with low baseline levels of vitamin D |
| Camargo et al. [21] |
2021 |
Randomized controlled trials |
775 |
Adults |
40 |
Vitamin D supplementation was ineffective in reducing the rate of asthma exacerbations in the participants |
| Ducharme et al. [14] |
2019 |
Randomized controlled trial |
47 |
Children |
7 |
No significant decrease in asthma exacerbation rates competent in the treatment |
| Forno et al. [15] |
2020 |
Randomized controlled trials |
192 |
Adults and children |
12 |
No change in exacerbations after supplementing vitamin D |
| Han et al. [13] |
2017 |
Cross-sectional study |
678 |
Children (six to 18 years) |
15 |
Vitamin D deficiency was associated with more likelihood of having severe asthma flare-ups |
| Jaura et al. [18] |
2020 |
Metanalysis |
764 |
Adults |
variable |
Vitamin D supplementation led to a reduced asthma exacerbation rate in patients having low baseline vitamin D levels |
| Jensen et al. [17] |
2016 |
Randomized controlled trials |
22 |
Children |
6 |
No significant difference in rescue inhaler or corticosteroid uses between the treatment group and control group |
| Jolliffe et al. [4] |
2017 |
Metanalysis |
955 |
Adults |
variable |
Supplementing vitamin D reduces the rate of asthma flare-up requiring corticosteroid use in participants with low baseline levels of vitamin D |
| Luo et al. [5] |
2015 |
Metanalysis of randomized controlled trials |
903 |
Adults and children |
variable |
No improvement in asthma exacerbation with vitamin D supplementation |
| Martineau et al. [19] |
2016 |
Systematic review |
680 |
Adults and children |
variable |
Supplementing vitamin D reduces the rate of asthma flare-up requiring corticosteroid use in the participants |
| Puranik et al. [1] |
2017 |
Observational studies |
148 |
children |
6 |
Low levels of the vitamin were present in the children during an asthma exacerbation. Supplementing Vitamin D in asthmatic children did not lead to a reduction in asthma exacerbation rates. |
| Solidoro et al. [12] |
2017 |
Two-phase cohort study |
119 |
Adults |
12 |
Low levels of vitamin D are found in most asthma patients. A significant reduction in asthma exacerbation was found in participants with baseline low levels of vitamin D. |
| Turkeli et al. [11] |
2016 |
Cross-sectional study |
230 |
children |
3 |
Patients with low levels of vitamin D were likely to have an asthma exacerbation |
| van Brakel et al. [2] |
2020 |
Systematic reviews |
2501 |
Adults and children |
variable |
No improvement in asthma control or quality of life with vitamin D supplements |
| Wang et al. [18] |
2019 |
Randomized controlled trials |
1421 |
Adults and children |
variable |
A significant reduction was found in adult asthmatic patients. No significant reduction in the pediatric participants. |
